Cellular and Molecular Life Sciences

, Volume 64, Issue 1, pp 66–76

Receptor communication within the lymphocyte plasma membrane: a role for the thrombospondin family of matricellular proteins

Review

DOI: 10.1007/s00018-006-6255-8

Cite this article as:
Forslöw, A., Liu, Z. & Sundqvist, K.G. Cell. Mol. Life Sci. (2007) 64: 66. doi:10.1007/s00018-006-6255-8

Abstract.

Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related protein, calreticulin and integrin-associated protein.

Keywords.

Thrombospondinlymphocyteextracellular matrixadhesionintegrin-associated proteinantigen-presenting cell

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Department of Laboratory Medicine, Division of Clinical ImmunologyKarolinska Institute at Karolinska University Hospital HuddingeStockholmSweden