Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 22, pp 2597–2607

Structural genomics for membrane proteins

Review

DOI: 10.1007/s00018-006-6252-y

Cite this article as:
Lundstrom, K. Cell. Mol. Life Sci. (2006) 63: 2597. doi:10.1007/s00018-006-6252-y

Abstract.

Structure-based drug discovery has proven useful in improving and shortening the drug development process. The approach of structural genomics to study a large number of targets in parallel has been commonly applied to protein families and even whole genomes. Paradoxically, although membrane proteins represent the largest type of drug targets, up to 70% today, determination of their structure has been modest compared to that of soluble proteins. Because membrane proteins are important for drug discovery an emphasis has been placed on developing technologies and methods to determine membrane protein structures. Several structural genomics initiatives have been established, focusing on the structural biology of membrane proteins.

Keywords.

Structural genomicsmembrane proteinsnetworksrecombinant protein expressionpurificationstructure determination

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.BioXtalEpalingesSwitzerland
  2. 2.Flamel TechnologiesVénissieuxFrance