Visions & Reflections

Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 17, pp 1933-1936

First online:

DNA methylation of fly genes and transposons

  • M. MandrioliAffiliated withDipartimento di Biologia Animale, Università di Modena e Reggio Emilia Email author 
  • , F. BorsattiAffiliated withDipartimento di Biologia Animale, Università di Modena e Reggio Emilia

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The use of anti-5-methylcytosine antibodies in affinity columns allowed the identification of methylated sequences in the genome of Drosophila melanogaster adults. In view of the presence of transposable elements amongst the identified sequences, it has been suggested that DNA methylation is involved in transposon control in the fly genome. On the contrary, a reanalysis of these data furnishes several intriguing elements that could raise new questions about the role that DNA methylation plays in the fly genome. The aim of the present paper is to discuss some features that emerge from the analysis of the identified methylated sequences.


DNA methylation gene expression transposon silencing development cytosine methylation function Drosophila melanogaster