Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 16, pp 1823–1832

The cellular functions of clathrin


DOI: 10.1007/s00018-005-5587-0

Cite this article as:
Royle, S.J. Cell. Mol. Life Sci. (2006) 63: 1823. doi:10.1007/s00018-005-5587-0


Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.



Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.MRC Laboratory of Molecular BiologyCambridgeUnited Kingdom