Cellular and Molecular Life Sciences

, 63:565

Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function

  • P. W. F. Hadoke
  • L. Macdonald
  • J. J. Logie
  • G. R. Small
  • A. R. Dover
  • B. R. Walker
Review

DOI: 10.1007/s00018-005-5427-2

Cite this article as:
Hadoke, P.W.F., Macdonald, L., Logie, J.J. et al. Cell. Mol. Life Sci. (2006) 63: 565. doi:10.1007/s00018-005-5427-2

Abstract.

The ability of glucocorticoids to directly alter arterial function, structure and the inflammatory response to vascular injury may contribute to their well-established link with the development of cardiovascular disease. Recent studies have emphasised the importance of tissue-specific regulation of glucocorticoid availability by the 11 β-hydroxysteroid dehydrogenase (11HSD) isozymes, which inter-convert active glucocorticoids and their inactive metabolites. The expression of both type 1 and type 2 11HSDs in the arterial wall suggests that prereceptor metabolism of glucocorticoids may have a direct impact on vascular physiology. Indeed there is evidence that 11HSDs influence glucocorticoid-mediated changes in vascular contractility, vascular structure, the inflammatory response to injury and the growth of new blood vessels. Hence, inhibition of 11HSD isozymes may provide a novel therapeutic target in vascular disease.

Key words.

11β-Hydroxysteroid dehydrogenaseinflammationvascular contractilityangiogenesiscardiovascular disease

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  • P. W. F. Hadoke
    • 1
  • L. Macdonald
    • 1
  • J. J. Logie
    • 1
  • G. R. Small
    • 1
  • A. R. Dover
    • 1
  • B. R. Walker
    • 1
  1. 1.Endocrinology Unit, Centre for Cardiovascular ScienceEdinburgh University, The Queen’s Medical Research InstituteEdinburghScotland (United Kingdom)