, Volume 63, Issue 1, pp 6-11,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 27 Dec 2005

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2


Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.

Received 12 September 2005; received after revision 25 October 2005; accepted 31 October 2005