Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 19, pp 2325–2338

Molecular mechanisms of lipoprotein receptor signalling


DOI: 10.1007/s00018-005-5231-z

Cite this article as:
May, P., Herz, J. & Bock, H.H. Cell. Mol. Life Sci. (2005) 62: 2325. doi:10.1007/s00018-005-5231-z


The low-density lipoprotein (LDL) receptor is the prototype of a classical endocytosis receptor that mediates the uptake of extracellular ligands. Other members of the LDL receptor gene family, on the other hand, have been shown to regulate intracellular signalling cascades. Among these are the LDL receptor-related protein 1, LRP1, a promiscuous and ubiquitously expressed receptor which is critically involved in a multitude of diverse physiological processes; the Reelin receptors ApoER2 and VLDL receptor, which participate in neuronal development; and megalin, a multifunctional receptor expressed in various epithelia. In this review, we focus on recent developments that highlight similarities and differences between these related receptors and their biological function, and discuss open questions as to the underlying molecular mechanisms.

Key words.

LRPApoER2VLDLRmegalinPDGFReelinDab1MAP kinasesignal transductionendocytosisatherosclerosisdevelopmentneuronal migrationsynapsegamma-secretaseapolipoprotein EAlzheimer’s disease

Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  1. 1.Zentrum für Neurowissenschaften (ZfN)Albert-Ludwigs-Universität FreiburgFreiburgGermany
  2. 2.Medizinische Klinik IIUniversitätsklinikumFreiburgGermany
  3. 3.Department of Molecular GeneticsUT Southwestern Medical Center at DallasUSA