Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 11, pp 1247–1259

δ-Protocadherins: a gene family expressed differentially in the mouse brain

Authors

  • K. Vanhalst
    • Department for Molecular Biomedical ResearchVIB-Ghent University Technologiepark 927B
    • European Patent Office
  • P. Kools
    • Department for Molecular Biomedical ResearchVIB-Ghent University Technologiepark 927B
    • European Patent Office
  • K. Staes
    • Department for Molecular Biomedical ResearchVIB-Ghent University Technologiepark 927B
  • F. van Roy
    • Department for Molecular Biomedical ResearchVIB-Ghent University Technologiepark 927B
    • Institute of Anatomy IUniversity of Jena School of Medicine
Research Article

DOI: 10.1007/s00018-005-5021-7

Cite this article as:
Vanhalst, K., Kools, P., Staes, K. et al. CMLS, Cell. Mol. Life Sci. (2005) 62: 1247. doi:10.1007/s00018-005-5021-7

Abstract.

Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the δ-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named δ1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and δ2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the δ1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1α. Like most classic cadherins, each of three δ1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other δ1-protocadherins. Together, these results suggest that the members of the δ1-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.

Key words.

Cell adhesioncene structurealternative splicingprotein phosphatase-1αbrain developmentexpression pattern
Download to read the full article text

Copyright information

© Birkhäuser Verlag, Basel 2005