, Volume 62, Issue 10, pp 1100-1108
Date: 09 Mar 2005

Wnt signaling: multiple functions in neural development

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Abstract.

Wnt signaling has proven to be essential for neural development at various stages and across species. Wnts are involved in morphogenesis and patterning, and their proliferation-promoting role is a key function in stem cell maintenance and the expansion of progenitor pools. Moreover, Wnt signaling is involved in differentiation processes and lineage decision events during both central and peripheral nervous system development. Additionally, several reports point to a role of Wnt signaling in axon guidance and neurite outgrowth. This article reviews and consolidates the existing evidence for the functions of Wnt signaling in neural development.

Received 10 December 2004; received after revision 19 January 2005; accepted 21 January 2005