Regulation of food intake by oleoylethanolamide

  • J. Lo Verme
  • S. Gaetani
  • J. Fu
  • F. Oveisi
  • K. Burton
  • D. Piomelli
Review

DOI: 10.1007/s00018-004-4494-0

Cite this article as:
Lo Verme, J., Gaetani, S., Fu, J. et al. CMLS, Cell. Mol. Life Sci. (2005) 62: 708. doi:10.1007/s00018-004-4494-0

Abstract.

Oleoylethanolamide (OEA), the naturally occurring amide of ethanolamine and oleic acid, is an endogenous lipid that modulates feeding, body weight and lipid metabolism by binding with high affinity to the ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-α). In the present article, we describe the biochemical pathways responsible for the initiation and termination of OEA signaling, and outline the pharmacological properties of this compound in relation to its ability to activate PPAR-α. Finally, we discuss the possible role of OEA as a peripheral satiety hormone.

Key words.

Oleoylethanolamidepalmitoylethanolamideperoxisome proliferator-activated receptor-alpha (PPAR-α)lipidfeedingsatietyenergy balancemetabolism

Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  • J. Lo Verme
    • 1
  • S. Gaetani
    • 1
    • 3
  • J. Fu
    • 1
  • F. Oveisi
    • 1
  • K. Burton
    • 1
  • D. Piomelli
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of CaliforniaIrvineUSA
  2. 2.Center for the Neurobiology of Learning and MemoryUniversity of CaliforniaIrvineUSA
  3. 3.Department of Human Physiology and PharmacologyUniversity of Rome “La Sapienza”RomaItaly