The role of insulin and IGF-1 signaling in longevity
- Cite this article as:
- Katic, M. & Kahn, C.R. CMLS, Cell. Mol. Life Sci. (2005) 62: 320. doi:10.1007/s00018-004-4297-y
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There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.