Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 19, pp 2597–2613

Biological functions of the ING family tumor suppressors


DOI: 10.1007/s00018-004-4199-4

Cite this article as:
Campos, E.I., Chin, M.Y., Kuo, W.H. et al. CMLS, Cell. Mol. Life Sci. (2004) 61: 2597. doi:10.1007/s00018-004-4199-4


Early studies of the inhibitor of growth 1 (ING1) gene, the founding member of the ING tumor suppressor family, demonstrated that this gene plays an important role in apoptosis and cellular senescence. Four other related genes have since been identified and found to be involved in various biological activities, including cell cycle arrest, regulation of gene transcription, DNA repair and apoptosis. The biochemical functions of ING proteins as histone acetyltransferases and histone deacetylase co-factors ties this new tumor suppressor family to the regulation of transcription, cell cycle check-points, DNA repair and apoptosis. This review is aimed at summarizing the known biological functions of the ING tumor suppressors and the signalling pathways that they involve.

Key words.

ING p53 tumor suppressor cell cycle DNA repair apoptosis histone acetylation 

Copyright information

© Birkhäuser Verlag, Basel 2004

Authors and Affiliations

  • E. I. Campos
    • 1
  • M. Y. Chin
    • 1
  • W. H. Kuo
    • 1
  • G. Li
    • 1
    • 2
  1. 1.Department of Medicine, Division of DermatologyUniversity of British ColumbiaVancouverCanada
  2. 2.Jack Bell Research CentreVancouverCanada

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