Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 19, pp 2485–2496

An update on the biology and physiology of resistin


DOI: 10.1007/s00018-004-4083-2

Cite this article as:
Adeghate, E. CMLS, Cell. Mol. Life Sci. (2004) 61: 2485. doi:10.1007/s00018-004-4083-2


Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules α, β and γ in structure and function. Resistin is produced by white and brown adipose tissues but has also has been identified in several other tissues, including the hypothalamus, pituitary and adrenal glands, pancreas, gastrointestinal tract, myocytes, spleen, white blood cells and plasma. The tissue level of resistin is decreased by insulin, cytokines such as tumour necrosis factor α, endothelin-1 and increased by growth and gonadal hormones, hyperglycaemia, male gender and some proinflammatory cytokines, such as interleukin-6 and lipopolysaccharide. Resistin antagonizes insulin action, and it is downregulated by rosiglitazone and peroxisome proliferator-activated receptor γ agonists. Since evidence of a direct link between resistin genotype and human diabetes is still weak, more molecular, physiological and clinical studies are needed to determine the role of resistin in the aetiology of type 2 diabetes.

Key words.

Resistininsulin resistanceobesitydiabetes mellitusglucose metabolism

Copyright information

© Birkhäuser Verlag, Basel 2004

Authors and Affiliations

  1. 1.Department of Anatomy, Faculty of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates