Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 7, pp 737–749

All in the family: aldose reductase and closely related aldo-keto reductases

Multi-author Review

DOI: 10.1007/s00018-003-3402-3

Cite this article as:
Petrash, J.M. CMLS, Cell. Mol. Life Sci. (2004) 61: 737. doi:10.1007/s00018-003-3402-3

Abstract

Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. In addition to polyol synthesis, aldose reductase may have multiple other activities that intersect with signal processing and oxidative defense mechanisms. Multiple aldose reductase-like proteins have been discovered to have structures and catalytic properties that broadly overlap those of aldose reductase. This chapter will summarize new insights into properties and functions of aldose reductase and closely related members of the aldo-keto reductase enzyme superfamily.

Aldo-keto reductase diabetes cancer adrenal gland vas deferens eye 

Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual Sciences, Department of GeneticsWashington University School of MedicineSt. LouisUSA