Review

Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 7, pp 822-842

The common and distinct target genes of the p53 family transcription factors

  • K. HarmsAffiliated withDepartment of Cell Biology, University of Alabama at Birmingham
  • , S. NozellAffiliated withDepartment of Cell Biology, University of Alabama at Birmingham
  • , X. ChenAffiliated withDepartment of Cell Biology, University of Alabama at Birmingham Email author 

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Abstract

p53 is the most commonly mutated gene in human cancer. After activation by cellular stresses such as DNA damage or oncogene activation, p53, a sequence-specific DNA-binding protein, induces the expression of target genes which mediate tumor suppression. Two recently identified p53 homologues, p63 and p73, appear to function similarly to p53, that is, they both activate target gene expression and suppress cell growth when overexpressed; however, the p63 and p73 genes are rarely mutated in human cancer and do not adhere to Knudson’s classical model of a tumor suppressor gene. Recently, exciting observations suggest nonoverlapping functions for the family members. Herein, we outline the recent literatures identifying and characterizing both the common and distinct target genes of the p53 family transcription factors in relation to their signaling pathways.

p53 p63 p73 transcription cell cycle arrest apoptosis development