Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 12, pp 2604–2621

The Art of War: Innate and adaptive immune responses


DOI: 10.1007/s00018-003-3180-y

Cite this article as:
Dempsey, P.W., Vaidya, S.A. & Cheng, G. CMLS, Cell. Mol. Life Sci. (2003) 60: 2604. doi:10.1007/s00018-003-3180-y


Research over the last several years has greatly advanced our understanding of the mechanisms by which the immune system functions. There exist two main branches of immunity, termed innate and adaptive immunity. Innate immunity uses the genetic memory of germline-encoded receptors to recognize the molecular patterns of common pathogens. Adaptive immunity, akin to somatic memory, is a complex system by which the body learns to recognize a pathogen’s unique antigens and builds an antigen specific response to destroy it. The effective development of the overall immune response depends on careful interplay and regulation between innate and adaptive immunity. Here we review our current understanding of how these integrated systems distinguish targets against which a response is appropriate and neutralize potentially pathogenic challenges.

Pathogen recognitioninnate activationhost defenseantigen presentationimmunoregulation

Copyright information

© Birkhäuser-Verlag Basel 2003

Authors and Affiliations

  1. 1.Department of Microbiology, Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesUSA