Review

Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 1, pp 49-68

First online:

Overview of mammalian zinc transporters

  • T. KambeAffiliated withDivision of Integrated Life Science, Graduate School of Biostudies, Kyoto University Email author 
  • , Y. Yamaguchi-IwaiAffiliated withDivision of Integrated Life Science, Graduate School of Biostudies, Kyoto University
  • , R. SasakiAffiliated withDepartment of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture
  • , M. NagaoAffiliated withDivision of Integrated Life Science, Graduate School of Biostudies, Kyoto University

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Abstract

In recent years, a number of mammalian zinc transporters have been identified, and candidate genes are rapidly growing. These transporters are classified into two families: ZIP (ZRT, IRT-like protein) and CDF (cation diffusion facilitator). ZIP members facilitate zinc influx into the cytosol, while CDF members facilitate its efflux from the cytosol. Molecular characterization of the transporters has brought about major advances in our understanding of their physiological functions. Zinc metabolism is regulated primarily through zinc-dependent control of transcription, translation, and intracellular trafficking of transporters. Analyses of mice whose zinc transporter genes have been genetically disrupted and of the naturally occurring mutant mice with symptoms related to abnormal zinc metabolism have provided compelling evidence that some zinc transporters play critical roles in zinc homeostasis. In this review, we review the literature of mammalian zinc transporters with emphasis on very recent findings and elicit integrative knowledge of zinc homeostasis.

Mammalian zinc transporter ZIP uptake CDF ZnT efflux zinc homeostasis