Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 12, pp 2547–2560

The causes of Charcot-Marie-Tooth disease


DOI: 10.1007/s00018-003-3133-5

Cite this article as:
Young, P. & Suter, U. CMLS, Cell. Mol. Life Sci. (2003) 60: 2547. doi:10.1007/s00018-003-3133-5


Charcot-Marie-Tooth (CMT) disease serves as the summary term for the most frequent forms of inherited peripheral neuropathies that affect motor and sensory nerves. In the last 12 years, 14 genes have been identified that cause different CMT subforms. The genes found initially are predominantly responsible for demyelinating and dysmyelinating neuropathies. Genes affected in axonal and rare forms of CMT have only recently been identified. In this review, we will focus on the currently known genes that are associated with CMT syndromes with regards to their genetics and function.

Myelin peripheral nervous system Schwann cell neurodegeneration Charcot-Marie-Tooth disease hereditary neuropathy axon degeneration 

Copyright information

© Birkhäuser-Verlag Basel 2003

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of MünsterMünsterGermany
  2. 2.Institute of Cell Biology, Department of BiologySwiss Federal Institute of TechnologyZürichSwitzerland