Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 11, pp 2465–2482

Receptor and nonreceptor protein tyrosine phosphatases in the nervous system

Authors

    • From the Child Study CenterYale University School of Medicine
  • P. J. Lombroso
    • From the Child Study CenterYale University School of Medicine
Review

DOI: 10.1007/s00018-003-3123-7

Cite this article as:
Paul, S. & Lombroso, P.J. CMLS, Cell. Mol. Life Sci. (2003) 60: 2465. doi:10.1007/s00018-003-3123-7

Abstract

Protein tyrosine phosphatases (PTPs) have emerged as a new class of signaling molecules that play important roles in the development and function of the central nervous system. They include both tyrosine-specific and dual-specific phosphatases. Based on their cellular localization they are also classified as receptor-like or intracellular PTP. However, the intracellular mechanisms by which these PTPs regulate cellular signaling pathways are not well understood. Evidence gathered to date provides some insight into the physiological function of these PTPs in the nervous system. In this review, we outline what is currently known about the functional role of PTPs expressed in the brain.

Receptor PTPsintracellular tyrosine phosphatasedual-specificity phosphatasesnervous systemintracellular signaling

Copyright information

© Birkhäuser-Verlag Basel 2003