Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 1, pp 35–48

Neurotrophins and their receptors: signaling trios in complex biological systems


DOI: 10.1007/s00018-003-3099-3

Cite this article as:
Teng, K.K. & Hempstead, B.L. CMLS, Cell. Mol. Life Sci. (2004) 61: 35. doi:10.1007/s00018-003-3099-3


The neurotrophins, a class of four related growth factors, utilize a dual receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated p75NTR to modulate diverse and sometimes opposing biological actions. The identification of novel ligands for p75NTR, unconventional mechanisms for Trk activation and unique signaling intermediates further underscores the complex nature of neurotrophin: receptor interactions, as well as their functions within and outside of the nervous systems. This review summarizes recent surprises of how ligand-receptor pairing may affect diverse developmental events, regulate response to injury and extend their influence on memory and learning.

NGF BDNF NT-3 NT-4 p75NTR Trk nervous system vascular biology 

Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  1. 1.Department of MedicineWeill Medical College of Cornell UniversityNew YorkUSA