Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 7, pp 1322-1332

Development and differentiation of the intestinal epithelium

  • P. de Santa BarbaraAffiliated withInstitut de Génétique Humaine, UPR 1142, CNRS Email author 
  • , G. R. van den BrinkAffiliated withLaboratory for Experimental Internal Medicine, Academic Medical Center
  • , D. J. RobertsAffiliated withDepartment of Pathology, Harvard Medical School and Brigham and Women's Hospital

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The gastrointestinal tract develops from a simple tube to a complex organ with patterns of differentiation along four axes of asymmetry. The organ is composed of all three germ layers signaling to each other during development to form the adult structure. The gut epithelium is a constitutively developing tissue, constantly differentiating from a stem cell in a progenitor pool throughout the life of the organism. Signals from the adjacent mesoderm and between epithelial cells are required for normal orderly development/differentiation, homeostasis, and apoptosis. Embryonically important patterning factors are used during adult stages for these processes. Such critical pathways as the hedgehog, bone morphogenetic protein, Notch, Sox, and Wnt systems are used both in embryologic and adult times of gut development. We focus on and review the roles of these factors in gut epithelial cell development and differentiation.

Visceral endoderm intestinal epithelium signaling pathways BMP Hh HOX Sox Wnt/β-catenin epithelial-mesenchymal interaction