Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 8, pp 1285–1295

ABCA2: a candidate regulator of neural transmembrane lipid transport

  • G. Schmitz
  • W. E. Kaminski

DOI: 10.1007/s00018-002-8508-5

Cite this article as:
Schmitz, G. & Kaminski, W. CMLS, Cell. Mol. Life Sci. (2002) 59: 1285. doi:10.1007/s00018-002-8508-5

Abstract.

Studies in the past years have implicated multispan transmembrane transport molecules of the ATP binding cassette (ABC) transporter family in cellular lipid export processes. The prototypic ABC transporter ABCA1 has recently been demonstrated to act as a major facilitator of cellular cholesterol and phospholipid export. Moreover, the transporter ABCA4 (ABCR) plays a pivotal role in retinaldehyde processing, and ABCA3 has recently implicated in lung surfactant processing. These pioneering observations have directed considerable attention to the A subfamily of ABC proteins. ABCA2 is the codefining member of the ABC A-transporter subclass. Although known for some time, it was not until recently that its complete molecular structure was established. Unlike other ABC A-subfamily members, ABCA2 is predominantly expressed in the brain and neural tissues. The unique expression profile together with available structural data suggest roles for this largest known ABC protein in neural transmembrane lipid export.

Key words. ABC transporter; ABCA2; macrophage; cholesterol; neural lipid transport; neuropathy; myelination.

Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • G. Schmitz
    • 1
  • W. E. Kaminski
    • 1
  1. 1.Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg (Germany), Fax + 49 941 944 6202, e-mail: gerd.schmitz@klinik.uni-regensburg.deDE