RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease
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Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation endproducts, amyloid β peptide and the family of β sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.
- RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease
Cellular and Molecular Life Sciences CMLS
Volume 59, Issue 7 , pp 1117-1128
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- Birkhäuser Verlag
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- Key words: Receptor; diabetes; vasculopathy; atherosclerosis; immunoglobulin; superfamily; inflammation; cancer.
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- A1. College of Physicians & Surgeons, Columbia University, 630 W. 168th Street, P&S 17-401, New York, NY 10032 (USA), Fax: + 1212 305 5337, e-mail: email@example.com, US