Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 7, pp 1117–1128

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

  • L. G. Bucciarelli
  • T. Wendt
  • L. Rong
  • E. Lalla
  • M. A. Hofmann
  • M. T. Goova
  • A. Taguchi
  • S. F. Yan
  • S. D. Yan
  • D. M. Stern
  • A. M. Schmidt

DOI: 10.1007/s00018-002-8491-x

Cite this article as:
Bucciarelli, L., Wendt, T., Rong, L. et al. CMLS, Cell. Mol. Life Sci. (2002) 59: 1117. doi:10.1007/s00018-002-8491-x

Abstract:

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation endproducts, amyloid β peptide and the family of β sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

Key words: Receptor; diabetes; vasculopathy; atherosclerosis; immunoglobulin; superfamily; inflammation; cancer.

Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • L. G. Bucciarelli
    • 1
  • T. Wendt
    • 1
  • L. Rong
    • 1
  • E. Lalla
    • 1
  • M. A. Hofmann
    • 1
  • M. T. Goova
    • 1
  • A. Taguchi
    • 1
  • S. F. Yan
    • 1
  • S. D. Yan
    • 1
  • D. M. Stern
    • 1
  • A. M. Schmidt
    • 1
  1. 1.College of Physicians & Surgeons, Columbia University, 630 W. 168th Street, P&S 17-401, New York, NY 10032 (USA), Fax: + 1212 305 5337, e-mail: ams11@columbia.eduUS