Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 7, pp 1096–1116

New insights into the structure and function of fatty acid-binding proteins

  • A. W. Zimmerman
  • J. H. Veerkamp

DOI: 10.1007/s00018-002-8490-y

Cite this article as:
Zimmerman, A. & Veerkamp, J. CMLS, Cell. Mol. Life Sci. (2002) 59: 1096. doi:10.1007/s00018-002-8490-y

Abstract:

Fatty acid-binding proteins (FABPs) are members of a superfamily of lipid-binding proteins, and occur intracellularly in vertebrates and invertebrates. This review presents recent findings on the diversity of these FABPs and their proposed roles in fatty acid (FA) metabolism and other cellular processes. Special attention is paid to the structural features of the different mammalian FABP types and the physiological role of these proteins in FA transport, cell growth and differentiation, cellular signalling, gene transcription and cytoprotection. Additionally, data on FABP knockout mice and the implication of FABP in medicine are discussed.

Key words: Fatty acid-binding protein; fatty acid transfer; site-directed mutagenesis; gene transcription; cancer; diagnostic marker; signal transduction.

Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • A. W. Zimmerman
    • 1
  • J. H. Veerkamp
    • 1
  1. 1.Department of Biochemistry, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, Fax + 31 24 3540339, e-mail: A.Zimmerman@bioch.kun.nlNL