CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule
- S. Kijimoto-Ochiai
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This review, regards the low-affinity receptor CD23 as a C-type lectin and compares it with other C-type lectins and C-type lectin-like receptors. C-type lectins such as the asialoglycoprotein receptor, as well as the dendritic cell immunoreceptor and the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin on dendritic cell lectin, possess amino acid sequences which interact with Ca++ and sugar, and many of them possess an endocytosis signal sequence that includes tyrosine or serine in the cytoplasmic region. In contrast, natural killer receptors lack the Ca++ and sugar-binding amino acids but conserve homologous cysteines in the form of C-type lectin, and possess an immunoreceptor tyrosine-based inhibitory motif in the cytoplasmic region which inhibits killer activity when they recognize the self major histocompatibility (MHC) class I molecule. Since human CD23a form has a similar amino acid sequence, the possibility that this sequence is an endocytosis signal or an ITIM is discussed. The function of the reverse RGD and RGD-binding inhibitory peptide in human CD23 from the point of view of the relation between a C-type lectin and MHC class II molecules is also considered.
- CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule
Cellular and Molecular Life Sciences CMLS
Volume 59, Issue 4 , pp 648-664
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- Birkhäuser Verlag
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- Key words. Low-affinity receptor for IgE; CD23; NK receptor; C-type lectin(-like) domain; inverse RGD sequence; RGD-binding inhibitory peptide; ITIM, endocytosis signal.
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- S. Kijimoto-Ochiai (A1)
- Author Affiliations
- A1. Institute of Immunology and Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815 (Japan), JP