Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 1, pp 126–142

Regulation of cyclin-Cdk activity in mammalian cells

  • A.J. Obaya
  • J.M. Sedivy

DOI: 10.1007/s00018-002-8410-1

Cite this article as:
Obaya, A. & Sedivy, J. CMLS, Cell. Mol. Life Sci. (2002) 59: 126. doi:10.1007/s00018-002-8410-1


Cell cycle progression is driven by the coordinated regulation of the activities of cyclin-dependent kinases (Cdks). Of the several mechanisms known to regulate Cdk activity in response to external signals, regulation of cyclin gene expression, post-translational modification of Cdks by phosphorylation-dephosphorylation cascades, and the interaction of cyclin/Cdk complexes with protein inhibitors have been thoroughly studied. During recent years, much attention has also been given to mechanisms that regulate protein degradation by the ubiquitin/proteasome pathway, as well as to the regulation of subcellular localization of the proteins that comprise the intrinsic cell cycle clock. The purpose of the present review is to summarize the most important aspects of the various mechanisms implicated in cell cycle regulation.

Key words. Cell cycle; cyclin; Cdk; Cdk inhibitor; Cdk phosphorylation; Rb phosphorylation; E2F/Rb restriction point; ubiquitin-proteasome pathway; Cellular localization. 

Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • A.J. Obaya
    • 1
  • J.M. Sedivy
    • 2
  1. 1.Instituto Universitario de Oncologia IUOPA, Area de Fisiologia, Facultad de Medicina, Universidad de Oviedo, Oviedo 33006 (Spain), Fax +34 985 10 35 34, e-mail: ajobaya@correo.uniovi.esES
  2. 2.Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912 (USA)US

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