Inflammation Research

, Volume 46, Issue 6, pp 203–210

Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: Central and peripheral components

  • J. M. A. Laird
  • J. F. Herrero
  • P. Garcia de la Rubia
  • F. Cervero
Article

DOI: 10.1007/s000110050174

Cite this article as:
Laird, J., Herrero, J., Garcia de la Rubia, P. et al. Inflamm. res. (1997) 46: 203. doi:10.1007/s000110050174

Abstract

Objective and Design: To study the characteristics and site of the analgesic action of meloxicam.¶Subjects: Adult female Wistar rats.¶Treatment: Monoarthritis was induced (for behavioural studies) by injection of complete Freund's adjuvant into the ankle. Meloxicam was given for 5 days (0.1–4 mg/kg/day i.p.). Inflammation of the knee or paw (for electrophysiology) was induced with carrageenan. Meloxicam was given i.v. (4–64 mg/kg).¶Methods: Rats were tested daily for joint hyperalgesia, and hindlimb posture (behaviour). At post-mortem, joint stiffness, oedema and gastric lesions were assessed. In anaesthetised rats, nociceptive reflex responses to stimulation of the paw were compared (electrophysiology). Statistics were performed using one-way analysis of variance.¶Results: Meloxicam reduced swelling and stiffness of the inflamed joint, joint hyperalgesia (ID50 = 0.4 ± 0.4 mg/kg/day) and spontaneous pain-related behaviour. It also inhibited peripherally mediated reflex responses to stimulation of inflamed tissue (ID50 = 7.6 ± 0.8 mg/kg i.v.) without affecting centrally mediated reflexes.¶Conclusions: Systemic meloxicam produces analgesia largely via peripheral mechanisms. The rapidity of its actions indicates a direct effect on sensitised nociceptors.

Key words: Analgesia — Pain — Arthritis — Cyclooxygenase 

Copyright information

© Birkhäuser Verlag, Basel, 1997

Authors and Affiliations

  • J. M. A. Laird
    • 1
  • J. F. Herrero
    • 1
  • P. Garcia de la Rubia
    • 1
  • F. Cervero
    • 1
  1. 1.Department of Physiology and Pharmacology, Faculty of Medicine, University of Alcalá, Alcalá de Henares, E-28871 Madrid, Spain, Fax +34 1885 4525, e-mail: fflaird@alcala.esES