Inflammation Research

, Volume 63, Issue 9, pp 789–796

Safety and efficacy of high-dose leukocytapheresis in patients with refractory asthma

  • Tamotsu Ishizuka
  • Takeshi Hisada
  • Motoaki Hatori
  • Akio Koike
  • Kikuo Hanabuchi
  • Shinichi Matsuzaki
  • Yosuke Kamide
  • Mitsuyoshi Utsugi
  • Haruka Aoki
  • Reiko Yoshino
  • Noriko Yanagitani
  • Yasuhiko Koga
  • Akihiro Ono
  • Kyoichi Kaira
  • Noriaki Sunaga
  • Kunio Dobashi
  • Takahiro Tsuburai
  • Kazuo Akiyama
  • Masanobu Yamada
  • Kazuhiro Suzuki
  • Masatomo Mori
Original Research Paper

DOI: 10.1007/s00011-014-0753-1

Cite this article as:
Ishizuka, T., Hisada, T., Hatori, M. et al. Inflamm. Res. (2014) 63: 789. doi:10.1007/s00011-014-0753-1

Abstract

Objective and design

An open-label, non-randomized, single-arm study was performed to investigate the safety and efficacy of high-dose leukocytapheresis (pulse LCAP) for refractory asthma.

Subjects

Six patients who fulfilled the ATS workshop criteria for refractory asthma were enrolled and completed this clinical study.

Treatment

After 4 weeks of observation, pulse LCAP using a large LCAP filter, Cellsorba® CS-180S, was performed twice with a 1-week interval at a target dose of 5 L per treatment session.

Methods

The clinical response was assessed by monitoring the peak expiratory flow rate (PEFR) twice a day. The asthma control test (ACT) was used to evaluate the condition of asthma symptoms. The fraction of exhaled nitric oxide (FeNO) as a biomarker for eosinophilic airway inflammation was measured using a chemiluminescence analyzer.

Results

PEFR in the morning or the evening and the sum total of the score on the ACT were increased after two consecutive sessions of pulse LCAP. FeNO decreased after pulse LCAP.

Conclusions

The results suggest the efficacy of pulse LCAP for refractory asthma.

Keywords

Refractory asthmaLeukocytapheresis (LCAP)Peak expiratory flow rate (PEFR)Asthma control test (ACT)Fraction of exhaled nitric oxide (FeNO)

Copyright information

© Springer Basel 2014

Authors and Affiliations

  • Tamotsu Ishizuka
    • 1
    • 2
  • Takeshi Hisada
    • 1
  • Motoaki Hatori
    • 3
  • Akio Koike
    • 4
  • Kikuo Hanabuchi
    • 4
  • Shinichi Matsuzaki
    • 1
  • Yosuke Kamide
    • 1
  • Mitsuyoshi Utsugi
    • 1
  • Haruka Aoki
    • 1
  • Reiko Yoshino
    • 1
  • Noriko Yanagitani
    • 1
  • Yasuhiko Koga
    • 1
  • Akihiro Ono
    • 1
  • Kyoichi Kaira
    • 1
  • Noriaki Sunaga
    • 1
  • Kunio Dobashi
    • 1
  • Takahiro Tsuburai
    • 5
  • Kazuo Akiyama
    • 5
  • Masanobu Yamada
    • 1
  • Kazuhiro Suzuki
    • 3
  • Masatomo Mori
    • 1
  1. 1.Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineMaebashiJapan
  2. 2.Third Department of Internal Medicine, Faculty of Medical SciencesUniversity of FukuiFukuiJapan
  3. 3.Department of UrologyGunma University Graduate School of MedicineMaebashiJapan
  4. 4.Central SupplyGunma University HospitalMaebashiJapan
  5. 5.Clinical Research Center for Allergy and Rheumatology, National Hospital OrganizationSagamihara National HospitalSagamiharaJapan