Original Research Paper

Inflammation Research

, Volume 63, Issue 3, pp 191-195

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines

  • Malgorzata Gorska CiebiadaAffiliated withDepartment of Internal Medicine and Diabetology, Medical University of Lodz
  • , Marcin BarylskiAffiliated withDepartment of Internal Disease and Cardiological Rehabilitation, Medical University of Lodz
  • , Maciej CiebiadaAffiliated withDepartment of General and Oncological Pneumonology, Medical University of Lodz Email author 



Because antileukotrienes may inhibit inflammation, it is plausible that montelukast administered for a long time could suppress skin wheal and flare reaction, and thus, it should be discarded prior to the tests. This study assessed the effect of long-lasting treatment with montelukast alone or in combination with antihistamines on wheal and flare in skin pricks tests (SPT) in patients sensitized to perennial allergens.


We conducted a 32-week, double-blind, placebo-controlled, cross-over and randomized trial that implicated two arms: arm A, 20 patients received levocetirizine, montelukast with or without levocetirizine or placebo; arm B, 20 patients received desloratadine, montelukast with or without desloratadine or placebo. All treatment periods lasted 6 weeks and were separated by 2-week washouts. At baseline and on the last day of each treatment period, SPT were performed in all participants.


Both levocetirizine and desloratadine in monotherapy, or in combination with montelukast, were effective in reducing wheal and flare in SPT. Monotherapy with montelukast did not change the size of the wheal for either histamine or for house dust mites, in either arm of the study, but significantly reduced the size of flare for histamine in arm A. Addition of montelukast to antihistamine did not exceed efficacy of monotherapy with antihistamine in both arms of the study.


Since the size of wheal determines the results of SPT, montelukast, even taken for a long time, does not have to be discarded prior to the tests.


Allergic rhinitis Montelukast Antihistamine Skin prick test Inflammation