The association between the functional PTPN22 1858 C/T and MIF −173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) −173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA).
A meta-analysis was conducted on variant alleles versus common alleles of the PTPN22 1858 C/T and MIF −173 C/G polymorphisms across ten comparative studies, which containing 4,238 JIA patients and 6,012 normal control subjects.
Ten comparative studies, consisting of nine European, and one Turkish population, were included in his meta-analysis. Meta-analysis showed an association between the T allele of the PTPN22 1858 C/T polymorphism and JIA in Europeans [odds ratio (OR) 1.311, 95% confidence interval (CI) 1.205–1.427, P < 1 × 10−8]. In addition, meta-analysis revealed an association between the C allele of the MIF −173 C/G polymorphism and JIA in all subjects (OR 1.482, 95% CI 1.202–1.828, P = 2.3 × 10−4).
This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF −173 C/G polymorphism may be associated with susceptibility to JIA.
- Petty RE, Southwood TR, Baum J, et al. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol. 1998;25:1991–4.
- Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase. Lyp Blood. 1999;93:2013–24.
- Cloutier JF, Veillette A. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med. 1999;189:111–21. CrossRef
- Bottini N, Musumeci L, Alonso A, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004;36:337–8. CrossRef
- Donnelly SC, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol Med Today. 1997;3:502–7. CrossRef
- Donn RP, Shelley E, Ollier WE, Thomson W. A novel 5′-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2001;44:1782–5. CrossRef
- Donn R, Alourfi Z, De Benedetti F, et al. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:2402–9. CrossRef
- Thompson SD, Sudman M, Ramos PS, et al. The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum. 2010;62:3265–76. CrossRef
- Pazar B, Gergely P Jr, Nagy ZB, et al. Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients. Clin Exp Rheumatol. 2008;26:1146–52.
- Cinek O, Hradsky O, Ahmedov G, et al. No independent role of the −1123 G > C and + 2740 A > G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. Diabetes Res Clin Pract. 2007;76:297–303. CrossRef
- Seldin MF, Shigeta R, Laiho K, et al. Finnish case-control and family studies support PTPN22 R620 W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis. Genes Immun. 2005;6:720–2.
- Hinks A, Barton A, John S, et al. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Arthritis Rheum. 2005;52:1694–9. CrossRef
- Viken MK, Amundsen SS, Kvien TK, et al. Association analysis of the 1858C > T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases. Genes Immun. 2005;6:271–3. CrossRef
- Berdeli A, Ozyurek AR, Ulger Z, et al. Association of macrophage migration inhibitory factor gene -173 G/C polymorphism with prognosis in Turkish children with juvenile rheumatoid arthritis. Rheumatol Int. 2006;26:726–31. CrossRef
- Miterski B, Drynda S, Boschow G, et al. Complex genetic predisposition in adult and juvenile rheumatoid arthritis. BMC Genet. 2004;5:2. CrossRef
- Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34. CrossRef
- Davey Smith G, Egger M. Meta-analyses of randomised controlled trials. Lancet. 1997; 350:1182.
- DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88. CrossRef
- Egger M, Smith GD, Phillips AN. Meta-analysis: principles and procedures. BMJ. 1997;315:1533–7. CrossRef
- Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58. CrossRef
- Lee YH, Rho YH, Choi SJ, et al. The PTPN22 C1858T functional polymorphism and autoimmune diseases–a meta-analysis. Rheumatology (Oxford). 2007;46:49–56. CrossRef
- Meazza C, Travaglino P, Pignatti P, et al. Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:232–7. CrossRef
- The association between the functional PTPN22 1858 C/T and MIF −173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis
Volume 61, Issue 5 , pp 411-415
- Cover Date
- Print ISSN
- Online ISSN
- SP Birkhäuser Verlag Basel
- Additional Links
- Protein tyrosine phosphatase nonreceptor 22
- Migration inhibitory factor
- Juvenile idiopathic arthritis
- Industry Sectors
- Author Affiliations
- 1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea
- 2. Hanyang University Medical Center, Seoul, Korea