Inflammation Research

, Volume 60, Issue 7, pp 665–672

Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats

Authors

    • Department of PathologyTexas Tech University Health Sciences Center
    • Laura W. Bush Institute for Women’s Health, Texas Tech University Health Sciences Center
  • Christina Samathanam
    • Department of PathologyTexas Tech University Health Sciences Center
  • Owatha L. Tatum
    • Molecular Pathology ProgramTexas Tech University Health Sciences Center
  • Suzanne Graham
    • Department of PathologyTexas Tech University Health Sciences Center
  • Christine Tubb
    • Molecular Pathology ProgramTexas Tech University Health Sciences Center
  • Jay J. Cao
    • USDA ARS Grand Forks Human Nutrition Research Center
  • Dale M. Dunn
    • Department of PathologyTexas Tech University Health Sciences Center
  • Jia-Sheng Wang
    • Department of Environmental Health ScienceUniversity of Georgia
Original Research Paper

DOI: 10.1007/s00011-011-0320-y

Cite this article as:
Shen, C., Samathanam, C., Tatum, O.L. et al. Inflamm. Res. (2011) 60: 665. doi:10.1007/s00011-011-0320-y

Abstract

Objective

Green tea proposes anti-inflammatory properties which may attenuate chronic inflammation-induced fibrosis of vessels. This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation.

Treatments

Forty 3-month-old female rats were assigned to a 2 (placebo vs. lipopolysaccharide, administration) × 2 (no GTP vs. 0.5% GTP in drinking water) factorial design for 12 weeks.

Methods

Masson’s trichrome staining evaluated myocardial fibrosis in coronary vessels and surrounding myocardium. Whole blood specimens were counted for differentials. Spleen tumor necrosis factor-α (TNF-α) mRNA expression was determined by real-time RT–PCR. Data were analyzed by two-way analysis of variance (ANOVA) followed by mean separation procedures.

Results

After 12 weeks, lipopolysaccharide administration induced myocardial fibrosis in vessels and surrounding myocardium, spleen TNF-α mRNA expression, and leukocytes, while GTP supplementation in drinking water significantly averted such observation.

Conclusions

GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses.

Keywords

TeaDietary supplementInflammationHematology

Copyright information

© Springer Basel AG 2011