Inflammation Research

, Volume 60, Issue 3, pp 227–232

The modulatory effect of lipids and glucose on the neonatal immune response induced by Staphylococcus epidermidis

  • Berit Haase
  • Kirstin Faust
  • Mathias Heidemann
  • Tasja Scholz
  • Martin Demmert
  • Birte Tröger
  • Alexander Herz
  • Christoph Härtel
Original Research Paper

DOI: 10.1007/s00011-010-0258-5

Cite this article as:
Haase, B., Faust, K., Heidemann, M. et al. Inflamm. Res. (2011) 60: 227. doi:10.1007/s00011-010-0258-5

Abstract

Background

Parenteral nutrition is an important risk factor for late onset sepsis in neonates. This may be caused by the long-term need of central venous access but also through a potentially modulating effect of lipids and glucose on the immune function.

Objective

It was the aim of this study to characterize the effect of lipids and glucose on the neonatal immune response in an in vitro Staphylococcus epidermidis sepsis model using whole cord blood of healthy term infants and preterm infants.

Results

At the single cell level, IL-6, IL-8 and TNF-α expression of CD14+ cells was significantly increased upon addition of 1% lipids, while the addition of clinically meaningful lipid concentrations had no remarkable effect. When glucose was added to whole cord blood cultures, a dose-dependent effect was demonstrated for IL-8 expression but not for other cytokines.

Conclusions

These in vitro data suggest that the pro-inflammatory cytokine response to S. epidermidis may be modulated by lipids and glucose. Further studies are needed to investigate whether these findings are applicable to clinical settings and to evaluate the role of cytokine monitoring in infants receiving long-term parenteral nutrition.

Keywords

Staphylococcus epidermidisIntravenous lipidsGlucoseCytokine response

Abbreviations

IL

Interleukin

TNF

Tumor necrosis factor

S. epidermidis

Staphylococcus epidermidis

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Berit Haase
    • 1
  • Kirstin Faust
    • 1
  • Mathias Heidemann
    • 1
  • Tasja Scholz
    • 1
  • Martin Demmert
    • 1
  • Birte Tröger
    • 1
  • Alexander Herz
    • 1
  • Christoph Härtel
    • 1
  1. 1.Department of Paediatrics, University Hospital Schleswig–HolsteinUniversity of Lübeck Medical SchoolLübeckGermany