, Volume 60, Issue 1, pp 11-18
Date: 21 May 2010

Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis

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Abstract

Objective

To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.

Methods

We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model.

Results

We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), −881 (A/G, 3 studies), −826 (C/T, 3 studies), and −297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, −881, −297 with autoimmune and inflammatory diseases. An association of NFKBIA gene −826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97–3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07–4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78–6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78–10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22–3.36, P = 0.006).

Conclusion

This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene −826C/T polymorphism, but not with 2758A/G, −881A/G, and −279C/T.

Responsible Editor: John Di Battista.