Inflammation Research

, Volume 60, Issue 1, pp 11–18

Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis

  • Guo-Long Zhang
  • Yan-Feng Zou
  • Xiao-Liang Feng
  • He-Jian Shi
  • Xu-Feng Du
  • Min-Hua Shao
  • Yong Gu
  • Qing Zhou
Original Research Paper

DOI: 10.1007/s00011-010-0216-2

Cite this article as:
Zhang, GL., Zou, YF., Feng, XL. et al. Inflamm. Res. (2011) 60: 11. doi:10.1007/s00011-010-0216-2

Abstract

Objective

To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.

Methods

We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model.

Results

We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), −881 (A/G, 3 studies), −826 (C/T, 3 studies), and −297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, −881, −297 with autoimmune and inflammatory diseases. An association of NFKBIA gene −826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97–3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07–4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78–6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78–10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22–3.36, P = 0.006).

Conclusion

This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene −826C/T polymorphism, but not with 2758A/G, −881A/G, and −279C/T.

Keywords

NFKBIA Genetic polymorphisms Autoimmune Inflammatory diseases Meta-analysis 

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Guo-Long Zhang
    • 1
    • 3
  • Yan-Feng Zou
    • 2
  • Xiao-Liang Feng
    • 2
  • He-Jian Shi
    • 1
    • 3
  • Xu-Feng Du
    • 1
    • 3
  • Min-Hua Shao
    • 3
  • Yong Gu
    • 3
  • Qing Zhou
    • 1
    • 3
  1. 1.Department of DermatologyAffiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxiChina
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiChina
  3. 3.Department of DermatologyWuxi People’s HospitalWuxiChina

Personalised recommendations