Short Communication

Inflammation Research

, Volume 59, Issue 5, pp 335-338

First online:

Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

  • Annalisa MarcuzziAffiliated withPaediatric Division, Institute of Child Health, IRCCS Burlo Garofolo Email author 
  • , Giuliana DecortiAffiliated withDepartment of Life Sciences, University of Trieste
  • , Alessandra PontilloAffiliated withMedical Genetic Service, Institute of Child Health, IRCCS Burlo Garofolo
  • , Alessandro VenturaAffiliated withDepartment of Reproductive and Developmental Sciences, University of TriestePaediatric Division, Institute of Child Health, IRCCS Burlo Garofolo
  • , Alberto TommasiniAffiliated withDepartment of Reproductive and Developmental Sciences, University of TriestePaediatric Division, Institute of Child Health, IRCCS Burlo Garofolo

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Abstract

Objective

The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels.

Materials and methods

Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1β (IL-1β) secretion and serum cholesterol levels were measured.

Results

An increased production of the pro-inflammatory cytokine IL-1β (p < 0.05) and a rise in body temperature (p < 0.05) was observed, while, in parallel, serum cholesterol concentration significantly decreased (p < 0.05). These effects were completely reversed when animals were treated with exogenous isoprenoids.

Conclusions

In the mouse model of MKD, the inflammatory response is associated with a reduction in cholesterol levels, and hence this parameter could be used as an indicator of isoprenoid consumption. In addition, plant derived isoprenoids could represent candidate treatments for this disease.

Keywords

Cholesterol Inflammation Mevalonate kinase deficiency IL-1β Temperature