Inflammation Research

, Volume 59, Issue 5, pp 335–338

Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

  • Annalisa Marcuzzi
  • Giuliana Decorti
  • Alessandra Pontillo
  • Alessandro Ventura
  • Alberto Tommasini
Short Communication

DOI: 10.1007/s00011-010-0168-6

Cite this article as:
Marcuzzi, A., Decorti, G., Pontillo, A. et al. Inflamm. Res. (2010) 59: 335. doi:10.1007/s00011-010-0168-6

Abstract

Objective

The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels.

Materials and methods

Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1β (IL-1β) secretion and serum cholesterol levels were measured.

Results

An increased production of the pro-inflammatory cytokine IL-1β (p < 0.05) and a rise in body temperature (p < 0.05) was observed, while, in parallel, serum cholesterol concentration significantly decreased (p < 0.05). These effects were completely reversed when animals were treated with exogenous isoprenoids.

Conclusions

In the mouse model of MKD, the inflammatory response is associated with a reduction in cholesterol levels, and hence this parameter could be used as an indicator of isoprenoid consumption. In addition, plant derived isoprenoids could represent candidate treatments for this disease.

Keywords

CholesterolInflammationMevalonate kinase deficiencyIL-1βTemperature

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Annalisa Marcuzzi
    • 4
  • Giuliana Decorti
    • 2
  • Alessandra Pontillo
    • 3
  • Alessandro Ventura
    • 1
    • 4
  • Alberto Tommasini
    • 1
    • 4
  1. 1.Department of Reproductive and Developmental SciencesUniversity of TriesteTriesteItaly
  2. 2.Department of Life SciencesUniversity of TriesteTriesteItaly
  3. 3.Medical Genetic Service, Institute of Child HealthIRCCS Burlo GarofoloTriesteItaly
  4. 4.Paediatric Division, Institute of Child HealthIRCCS Burlo GarofoloTriesteItaly