Inflammation Research

, Volume 59, Issue 6, pp 463–469

Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation

  • Kristoffer Mads Henningsen
  • Brian Nilsson
  • Julia S. Johansen
  • Xu Chen
  • Steen Pehrson
  • Jesper Hastrup Svendsen
Original Research Paper

DOI: 10.1007/s00011-009-0146-z

Cite this article as:
Henningsen, K.M., Nilsson, B., Johansen, J.S. et al. Inflamm. Res. (2010) 59: 463. doi:10.1007/s00011-009-0146-z

Abstract

Aim

To study plasma YKL-40 in patients with atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation and to assess the predictive role of plasma YKL-40 and its changes after restoration of sinus rhythm (SR).

Methods

Forty-six patients (mean age 55 years, range 31–81) with paroxysmal/persistent AF were treated with RF catheter ablation; Holter monitoring for 14 days was performed before ablation and after 3 months. Recurrent symptomatic AF or atrial tachycardia >10 min was considered failure, and the patients were offered a second ablation session. YKL-40 was determined in plasma samples taken prior to ablation and at follow-up visits up to 12 months after ablation.

Results

After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. The patients with no recurrence of AF had significantly lower baseline plasma levels of YKL-40 prior to ablation compared to patients with recurrence of AF (31 vs. 62 μg/l, P = 0.029). Plasma YKL-40 was not an independent predictor of recurrence of AF after ablation. No significant changes in plasma YKL-40 levels were seen from baseline to follow-up at 12 months.

Conclusion

In patients with paroxysmal or persistent AF treated with catheter ablation, high plasma YKL-40 before ablation is associated with recurrence of AF.

Keywords

Atrial fibrillation Inflammation YKL-40 hs-CRP Radiofrequency catheter ablation 

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Kristoffer Mads Henningsen
    • 1
    • 2
  • Brian Nilsson
    • 1
  • Julia S. Johansen
    • 3
  • Xu Chen
    • 1
  • Steen Pehrson
    • 1
  • Jesper Hastrup Svendsen
    • 1
    • 2
    • 4
  1. 1.Department of Cardiology, Cardiac Catheterization Laboratory 2014, The Heart Centre, RigshospitaletUniversity of CopenhagenCopenhagen ØDenmark
  2. 2.The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC)CopenhagenDenmark
  3. 3.Department of Medicine O, Herlev HospitalUniversity of CopenhagenCopenhagenDenmark
  4. 4.Department of Surgery and Medicine, Faculty of Health SciencesUniversity of CopenhagenCopenhagenDenmark

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