Histamine intolerance: a metabolic disease?
- H. G. Schwelberger
- … show all 1 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To evaluate the evidence regarding the disease concept of histamine intolerance as a state of inadequate histamine inactivation.
Keyword-based systematic screening of the scientific literature and of public websites focusing on diagnostic and therapeutic procedures.
Histamine intolerance is commonly diagnosed based solely on subjective reporting of symptoms instead of following systematic diagnostic procedures based on objective laboratory and physical parameters. The only effective long-term therapy is avoidance of histamine-containing food.
The concept of histamine intolerance as a metabolic disease is in need of more experimental and clinical evidence and affected patients will benefit from a clear, evidence-based diagnostic and therapeutic regime.
- Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85:1185–96.
- Schwelberger HG. Histamine intolerance: overestimated or underestimated? Inflamm Res. 2009;58(Suppl 1):S51–2. CrossRef
- Amon U, Bangha E, Küster T, Menne A, Vollrath IB, Gibbs BF. Enteral histaminosis: clinical implications. Inflamm Res. 1999;47:291–5. CrossRef
- Sarkadi L. Histamine in food. In: Falus A, editors. Histamine: biology and medical aspects. Budapest: SpringMed Publishing, 2004: 176-85.
- Schwelberger HG. Histamine N-methyltransferase (HNMT) enzyme and gene. In: Falus A, editors. Histamine: biology and medical aspects. Budapest: SpringMed Publishing, 2004: 53-9.
- Schwelberger HG. Diamine oxidase (DAO) enzyme and gene. In: Falus A, editor. Histamine: biology and medical aspects. Budapest: SpringMed Publishing; 2004. p. 43–52.
- Schwelberger HG, Drasche A, Petersen J, Raithel M. Genetic polymorphisms of histamine degrading enzymes: from small-scale screening to high-throughput routine testing. Inflamm Res. 2003;52(Suppl 1):S71–3. CrossRef
- Taylor SL. Histamine food poisoning: toxicology and clinical aspects. Crit Rev Toxicol. 1986;17:91–128. CrossRef
- Histamine intolerance: a metabolic disease?
Volume 59, Issue 2 Supplement, pp 219-221
- Cover Date
- Print ISSN
- Online ISSN
- SP Birkhäuser Verlag Basel
- Additional Links
- Histamine intolerance
- Histamine metabolism
- Diamine oxidase
- Histamine N-methyltransferase
- Industry Sectors
- Author Affiliations
- 1. Molecular Biology Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Schöpfstraße 41, 6020, Innsbruck, Austria