Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
To examine the trafficking of human circulating blood monocytes and their influence on the inflammation of periprosthetic tissues using a novel mouse–human chimera model.
Periprosthetic tissue and bone chips from patients with aseptic prosthetic loosening were implanted into the muscles of immune-deficient SCID mice depleted of host macrophages by periodic intraperitoneal injection of anti-asialo GM1 rabbit sera (ASGM1). Autologous patient peripheral blood monocytes (PBMCs) were labeled with PKH2 fluorescent dye and injected intraperitoneally into the implanted animals. Mice were sacrificed 14 days after PBMC transfusion for molecular and histological analyses.
Patient periprosthetic tissues were well tolerated in SCID mice and preserved a high level of viability. Cell trafficking studies revealed the accumulation of fluorescent PBMC within the xenografts, with total cell counts in the xenografts significantly increased following the systemic PBMC infusion. PBMC infusion also promoted the expression of IL-1, IL-6, TNFα, and RANK within the periprosthetic tissue.
Systemic PBMC migrated to the implanted periprosthetic tissues and contributed to the local inflammation. The data provide evidence that circulating blood monocytes may play a role in pathologic process during aseptic loosening of total joint replacement.
- Ingham E, Fisher J. The role of macrophages in osteolysis of total joint replacement. Biomaterials. 2005;26:1271–86. CrossRef
- Bauer TW, Schils J. The pathology of total joint arthroplasty. II. Mechanisms of implant failure. Skeletal Radiol. 1999;28:483–97. CrossRef
- Santavirta S, Konttinen YT, Bergroth V, Eskola A, Tallroth K, Lindholm TS. Aggressive granulomatous lesions associated with hip arthroplasty Immunopathological studies. J Bone Joint Surg Am. 1990;72:252–8.
- Kadoya Y, Revell PA, Kobayashi A, Al-Saffar N, Scott G, Freeman MA. Wear particulate species and bone loss in failed total joint arthroplasties. Clin Orthop Relat Res. 1997;340:118–29. CrossRef
- Shanbhag AS, Jacobs JJ, Glant TT, Gilbert JL, Black J, Galante JO. Composition and morphology of wear debris in failed uncemented total hip replacement. J Bone Joint Surg Br. 1994;76:60–7.
- Fang HW, Ho YC, Yang CB, Liu HL, Ho FY, Lu YC, et al. Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivites. J Biochem Biophys Methods. 2006;68:175–87. CrossRef
- Goldring SR, Schiller AL, Roelke M, Rourke CM, O’Neil DA, Harris WH. The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. J Bone Joint Surg Am. 1983;65:575–84.
- Santavirta S, Ceponis A, Solovieva SA, Hurri H, Jin J, Takagi M, et al. Periprosthetic microvasculature in loosening of total hip replacement. Arch Orthop Trauma Surg. 1996;115:286–9. CrossRef
- Anderson JM, Miller KM. Biomaterial biocompatibility and the macrophage. Biomaterials. 1984;5:5–10. CrossRef
- Laquerriere P, Grandjean-Laquerriere A, Jallot E, Balossier G, Frayssinet P, Guenounou M. Importance of hydroxyapatite particles characteristics on cytokines production by human monocytes in vitro. Biomaterials. 2003;24:2739–47. CrossRef
- Yang SY, Nasser S, Markel DC, Robbins PD, Wooley PH. Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor. J Bone Joint Surg Am. 2005;87:1088–97. CrossRef
- Geiler T, Kriegsmann J, Keyszer GM, Gay RE, Gay S. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum. 1994;37:1664–71. CrossRef
- Slezak SE, Horan PK. Fluorescent in vivo tracking of hematopoietic cells. Part I. Technical considerations. Blood. 1989;74:2172–7.
- Ren W, Yang SY, Wooley PH. A novel murine model of orthopaedic wear-debris associated osteolysis. Scand J Rheumatol. 2004;33:349–57. CrossRef
- Yang SY, Wu B, Mayton L, Mukherjee P, Robbins PD, Evans CH, et al. Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Ther. 2004;11:483–91. CrossRef
- Yang S, Wu B, Mayton L, Evans CH, Robbins PD, Wooley PH. IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model. Inflamm Res. 2002;51:342–50. CrossRef
- Harris WH. Wear and periprosthetic osteolysis: the problem. Clin Orthop Relat Res. 2001;393:66–70. CrossRef
- van Raay JJ, Rozing PM, Eulderink F. Tissue response to the failed Gerard double-cup. Histologic analysis of 40 uncemented hip arthroplasties. Acta Orthop Scand. 1993;64:268–72. CrossRef
- Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301:527–30. CrossRef
- Rollins BJ. Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease. Mol Med Today. 1996;2:198–204. CrossRef
- Sakai K, Matsuno H, Morita I, Nezuka T, Tsuji H, Shirai T, et al. Potential withdrawal of rheumatoid synovium by the induction of apoptosis using a novel in vivo model of rheumatoid arthritis. Arthritis Rheum. 1998;41:1251–7. CrossRef
- Koulouvaris P, Ly K, Ivashkiv LB, Bostrom MP, Nestor BJ, Sculco TP, et al. Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis. J Orthop Res. 2008;26:106–16. CrossRef
- Ishiguro N, Kojima T, Ito T, Saga S, Anma H, Kurokouchi K, et al. Macrophage activation and migration in interface tissue around loosening total hip arthroplasty components. J Biomed Mater Res. 1997;35:399–406. CrossRef
- Askenasy N, Farkas DL. Optical imaging of PKH-labeled hematopoietic cells in recipient bone marrow in vivo. Stem Cells. 2002;20:501–13. CrossRef
- Horan PK, Slezak SE. Stable cell membrane labelling. Nature. 1989;340:167–8. CrossRef
- Murphy WJ, Kumar V, Bennett M. Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection. J Exp Med. 1987;165:1212–7. CrossRef
- Sandhu J, Shpitz B, Gallinger S, Hozumi N. Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol. 1994;152:3806–13.
- Shpitz B, Fernandes BJ, Mullen JB, Roder JC, Gallinger S. Improved engraftment of human tumours in SCID mice pretreated with radiation and anti-asialo GM1. Anticancer Res. 1994;14:1927–34.
- Shpitz B, Chambers CA, Singhal AB, Hozumi N, Fernandes BJ, Roifman CM, et al. High level functional engraftment of severe combined immunodeficient mice with human peripheral blood lymphocytes following pretreatment with radiation and anti-asialo GM1. J Immunol Methods. 1994;169:1–15. CrossRef
- Yoshino H, Ueda T, Kawahata M, Kobayashi K, Ebihara Y, Manabe A, et al. Natural killer cell depletion by anti-asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid mice. Bone Marrow Transpl. 2000;26:1211–6. CrossRef
- Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation
Volume 58, Issue 12 , pp 837-844
- Cover Date
- Print ISSN
- Online ISSN
- SP Birkhäuser Verlag Basel
- Additional Links
- Cell migration
- Inflammatory models
- Industry Sectors
- Author Affiliations
- 1. Shandong University School of Medicine, 250012, Jinan, Shandong, China
- 2. Orthopaedic Research Institute, Via Christi Regional Medical Center, 929 N Saint Francis, Wichita, KS, 67214, USA
- 4. Department of Orthopaedic Surgery, Providence Hospital, Southfield, MI, USA
- 3. Department of Biological Sciences, Wichita State University, Wichita, KS, USA