Inflammation Research

, Volume 58, Issue 8, pp 503–512

Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?

Authors

  • Lenka Frol’ová
    • Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.
  • Karel SmetanaJr
    • Institute of Anatomy and Center of Cell Therapy and Tissue Repair, 1st Faculty of MedicineCharles University
  • Dana Borovská
    • Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.
  • Andrea Kitanovičová
    • Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.
  • Klára Klimešová
    • Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.
  • Ivana Janatková
    • Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of MedicineCharles University
  • Karin Malíčková
    • Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of MedicineCharles University
  • Milan Lukáš
    • Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of MedicineCharles University
    • IBD Clinical and Research Centre, ISCARE IVF
  • Pavel Drastich
    • Department of Gastroenterology and HepatologyInstitute of Clinical and Experimental Medicine
  • Zdeněk Beneš
    • 2nd Internal ClinicTeaching Thomayer Hospital
  • Ludmila Tučková
    • Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.
  • Joachim C. Manning
    • Institute of Physiological Chemistry, Faculty of Veterinary MedicineLudwig-Maximilians-University
  • Sabine André
    • Institute of Physiological Chemistry, Faculty of Veterinary MedicineLudwig-Maximilians-University
  • Hans-Joachim Gabius
    • Institute of Physiological Chemistry, Faculty of Veterinary MedicineLudwig-Maximilians-University
    • Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.
    • 1st Faculty of MedicineCharles University
Original Research Paper

DOI: 10.1007/s00011-009-0016-8

Cite this article as:
Frol’ová, L., Smetana, K., Borovská, D. et al. Inflamm. Res. (2009) 58: 503. doi:10.1007/s00011-009-0016-8

Abstract

Objective

It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.

Methods

Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.

Results

Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14+ cells.

Conclusion

Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.

Keywords

Crohn’s diseaseGalectin-3Disease markerMucosal immunityUlcerative colitis

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009