Original Research Paper

Inflammation Research

, Volume 58, Issue 8, pp 503-512

First online:

Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?

  • Lenka Frol’ováAffiliated withDepartment of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.
  • , Karel SmetanaJrAffiliated withInstitute of Anatomy and Center of Cell Therapy and Tissue Repair, 1st Faculty of Medicine, Charles University
  • , Dana BorovskáAffiliated withDepartment of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.
  • , Andrea KitanovičováAffiliated withDepartment of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.
  • , Klára KlimešováAffiliated withDepartment of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.
  • , Ivana JanatkováAffiliated withInstitute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of Medicine, Charles University
  • , Karin MalíčkováAffiliated withInstitute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of Medicine, Charles University
  • , Milan LukášAffiliated withInstitute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of Medicine, Charles UniversityIBD Clinical and Research Centre, ISCARE IVF
  • , Pavel DrastichAffiliated withDepartment of Gastroenterology and Hepatology, Institute of Clinical and Experimental Medicine
    • , Zdeněk BenešAffiliated with2nd Internal Clinic, Teaching Thomayer Hospital
    • , Ludmila TučkováAffiliated withDepartment of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.
    • , Joachim C. ManningAffiliated withInstitute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University
    • , Sabine AndréAffiliated withInstitute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University
    • , Hans-Joachim GabiusAffiliated withInstitute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University
    • , Helena Tlaskalová-HogenováAffiliated withDepartment of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.1st Faculty of Medicine, Charles University Email author 

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Abstract

Objective

It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.

Methods

Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.

Results

Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14+ cells.

Conclusion

Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.

Keywords

Crohn’s disease Galectin-3 Disease marker Mucosal immunity Ulcerative colitis