Inflammation Research

, Volume 58, Issue 8, pp 503–512

Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?

  • Lenka Frol’ová
  • Karel SmetanaJr
  • Dana Borovská
  • Andrea Kitanovičová
  • Klára Klimešová
  • Ivana Janatková
  • Karin Malíčková
  • Milan Lukáš
  • Pavel Drastich
  • Zdeněk Beneš
  • Ludmila Tučková
  • Joachim C. Manning
  • Sabine André
  • Hans-Joachim Gabius
  • Helena Tlaskalová-Hogenová
Original Research Paper

DOI: 10.1007/s00011-009-0016-8

Cite this article as:
Frol’ová, L., Smetana, K., Borovská, D. et al. Inflamm. Res. (2009) 58: 503. doi:10.1007/s00011-009-0016-8

Abstract

Objective

It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.

Methods

Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.

Results

Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14+ cells.

Conclusion

Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.

Keywords

Crohn’s diseaseGalectin-3Disease markerMucosal immunityUlcerative colitis

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Lenka Frol’ová
    • 1
  • Karel SmetanaJr
    • 3
  • Dana Borovská
    • 1
  • Andrea Kitanovičová
    • 1
  • Klára Klimešová
    • 1
  • Ivana Janatková
    • 4
  • Karin Malíčková
    • 4
  • Milan Lukáš
    • 4
    • 8
  • Pavel Drastich
    • 5
  • Zdeněk Beneš
    • 6
  • Ludmila Tučková
    • 1
  • Joachim C. Manning
    • 7
  • Sabine André
    • 7
  • Hans-Joachim Gabius
    • 7
  • Helena Tlaskalová-Hogenová
    • 1
    • 2
  1. 1.Department of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech Republic, v.v.i.Prague 4Czech Republic
  2. 2.1st Faculty of MedicineCharles UniversityPrague 2Czech Republic
  3. 3.Institute of Anatomy and Center of Cell Therapy and Tissue Repair, 1st Faculty of MedicineCharles UniversityPrague 2Czech Republic
  4. 4.Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital, 1st Faculty of MedicineCharles UniversityPrague 2Czech Republic
  5. 5.Department of Gastroenterology and HepatologyInstitute of Clinical and Experimental MedicinePrague 4Czech Republic
  6. 6.2nd Internal ClinicTeaching Thomayer HospitalPrague 4Czech Republic
  7. 7.Institute of Physiological Chemistry, Faculty of Veterinary MedicineLudwig-Maximilians-UniversityMunichGermany
  8. 8.IBD Clinical and Research Centre, ISCARE IVFPrague 7Czech Republic