Inflammation Research

, Volume 58, Issue 7, pp 385–393

Serial cytokine levels in patients with severe sepsis

  • Huang-Pin Wu
  • Chian-Kuang Chen
  • Kong Chung
  • Jo-Chi Tseng
  • Chung-Ching Hua
  • Yu-Chih Liu
  • Duen-Yau Chuang
  • Chung-Han Yang
Original Research Paper

DOI: 10.1007/s00011-009-0003-0

Cite this article as:
Wu, HP., Chen, CK., Chung, K. et al. Inflamm. Res. (2009) 58: 385. doi:10.1007/s00011-009-0003-0

Abstract

Objective and design

The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear.

Methods

Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-β1 from day 1 to day 7 were determined.

Results

IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality.

Conclusion

IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.

Keywords

Sepsis Cytokine Human Interleukin-6 Interleukin-10 Transforming growth factor-beta1 

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Huang-Pin Wu
    • 1
    • 2
    • 3
  • Chian-Kuang Chen
    • 3
    • 4
  • Kong Chung
    • 3
    • 4
  • Jo-Chi Tseng
    • 1
    • 2
    • 3
  • Chung-Ching Hua
    • 1
    • 2
    • 3
  • Yu-Chih Liu
    • 1
    • 2
    • 3
  • Duen-Yau Chuang
    • 5
  • Chung-Han Yang
    • 3
    • 6
  1. 1.Division of Pulmonary Medicine, Department of Internal MedicineChang Gung Memorial Hospital, KeelungKeelungTaiwan, ROC
  2. 2.Department of Respiratory TherapyChang Gung Memorial HospitalKeelungTaiwan, ROC
  3. 3.Chang Gung University College of MedicineTaoyuanTaiwan, ROC
  4. 4.Department of EmergenceChang Gung Memorial HospitalKeelungTaiwan, ROC
  5. 5.Department of ChemistryNational Chung-Hsing UniversityTaichungTaiwan, ROC
  6. 6.Division of Rheumatology, Department of Internal MedicineChang Gung Memorial HospitalKeelungTaiwan, ROC

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