Inflammation Research

, Volume 57, Issue 6, pp 266–271

Cytokine profile in collagen-induced arthritis: Differences between syngeneic and allogeneic pregnancy

  • D. Almeida González
  • A. Cabrera de León
  • C. Vázquez Moncholi
  • B. Brito Díaz
  • M. C. Rodríguez Pérez
  • A. Aguirre-Jaime
  • S. Domínguez Coello
  • A. González Hernández
Article

DOI: 10.1007/s00011-007-7197-9

Cite this article as:
González, D.A., de León, A.C., Moncholi, C.V. et al. Inflamm. res. (2008) 57: 266. doi:10.1007/s00011-007-7197-9

Abstract.

Objective:

To identify the differences in cytokine profile between allogeneic and syngeneic pregnancy in mice with collagen-induced arthritis (CIA).

Methods:

Mice (strain B10.RIII) were injected with bovine collagen. Females were mated with males of the same strain (syngeneic pregnancy) or with males of strain B10. Q (allogeneic pregnancy). Concentrations of cytokines were measured during pregnancy and after delivery, and the onset and evolution of arthritis was followed in all female animals throughout the study period.

Results:

In female mice that developed CIA, cytokine concentrations were lower in allogeneic pregnancies than syngeneic pregnancies. When paired cytokine concentrations were compared in each animal during and after pregnancy, MCP-1 was lower during gestation than after delivery in both groups of pregnant mice, IL-6 was lower during gestation than after delivery only in allogeneic pregnancies, and IL-10 was lower during gestation than after delivery in allogeneic pregnancies, whereas in syngeneic pregnancies IL-10 was higher during gestation than after delivery.

Conclusions:

Allogeneic pregnancy was associated with less arthritis because of lower concentrations of proinflammatory cytokines (IL-6 and others), not because of an increase in the concentration of antiinflammatory cytokines (IL-10).

Keywords:

ArthritisPregnancyAllogeneicSyngeneicCytokines

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • D. Almeida González
    • 1
  • A. Cabrera de León
    • 1
    • 2
    • 3
  • C. Vázquez Moncholi
    • 1
  • B. Brito Díaz
    • 1
  • M. C. Rodríguez Pérez
    • 1
  • A. Aguirre-Jaime
    • 1
  • S. Domínguez Coello
    • 1
  • A. González Hernández
    • 1
  1. 1.Research Unit, Hospital de La CandelariaSanta Cruz de TenerifeSpain
  2. 2.Hospital San Juan de Dios, Santa Cruz de TenerifeSanta Cruz de TenerifeSpain
  3. 3.School of MedicineUniversidad de La LagunaCanary IslandsSpain