Short Communication

Inflammation Research

, Volume 57, Issue 1, pp 1-3

First online:

Inflammation-induced enhancement of IgG immunoreactivity

  • N. M. MihaylovaAffiliated withDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences
  • , J. D. DimitrovAffiliated withDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences
  • , I. K. Djoumerska-AlexievaAffiliated withDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences
  • , T. L. VassilevAffiliated withDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract.

Natural polyreactive IgG antibodies are found in the sera of all healthy individuals. The in vitro exposure of pooled human IgG to protein-destabilizing chemical or physical factors has been previously shown to result in the exposure of their “hidden” polyspecificity. We hypothesize that such an enhancement of their pre-existing immunoreactivity may occur in vivo in the aggressive microenvironment of inflammation sites. An increase in the antigen binding intensity as well as of the number of recognized antigens was observed in the sera of IgG-infused immunodeficient SCID mice with induced local inflammation. The expansion of the IgG pathogen-binding repertoire may have important biological consequences.

Keywords:

IgG Natural antibodies Polyreactivity Inflammation