Inflammation Research

, Volume 57, Issue 1, pp 1–3

Inflammation-induced enhancement of IgG immunoreactivity

  • N. M. Mihaylova
  • J. D. Dimitrov
  • I. K. Djoumerska-Alexieva
  • T. L. Vassilev
Short Communication

DOI: 10.1007/s00011-007-6213-4

Cite this article as:
Mihaylova, N.M., Dimitrov, J.D., Djoumerska-Alexieva, I.K. et al. Inflamm. res. (2008) 57: 1. doi:10.1007/s00011-007-6213-4

Abstract.

Natural polyreactive IgG antibodies are found in the sera of all healthy individuals. The in vitro exposure of pooled human IgG to protein-destabilizing chemical or physical factors has been previously shown to result in the exposure of their “hidden” polyspecificity. We hypothesize that such an enhancement of their pre-existing immunoreactivity may occur in vivo in the aggressive microenvironment of inflammation sites. An increase in the antigen binding intensity as well as of the number of recognized antigens was observed in the sera of IgG-infused immunodeficient SCID mice with induced local inflammation. The expansion of the IgG pathogen-binding repertoire may have important biological consequences.

Keywords:

IgGNatural antibodiesPolyreactivityInflammation

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • N. M. Mihaylova
    • 1
  • J. D. Dimitrov
    • 1
  • I. K. Djoumerska-Alexieva
    • 1
  • T. L. Vassilev
    • 1
  1. 1.Department of Immunology, Stefan Angelov Institute of MicrobiologyBulgarian Academy of SciencesSofiaBulgaria