, Volume 56, Issue 6, pp 228-229

COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy

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Abstract.

Objective and design:

Low level laser therapy (LLLT) has been presented as a novel therapy to treat inflammation. Herein we studied the effect of LLLT on the COX-2 mRNA expression in subplantar tissue taken from rats treated with carrageenan.

Material:

The groups consisted of 32 rats: A 1 (Saline), A 2 (Carrageenan), A 3 (Carrageenan + laser 660 nm) and A 4 (Carrageenan + laser 684 nm).

Treatment:

A 3 and A 4 were irradiated in the first hour after carrageenan.

Methods:

The edema was measured by a plethysmometer and COX-2 mRNA was by RT-PCR. Statistical were evaluated by ANOVA and Tukey-Kramer Test.

Results:

Carrageenan increased both edema (A 1= 0.6 ± 0.04 vs. A 2= 2.24 ± 0.08) and COX-2 mRNA (A 1= 1.1 ± 0.26 vs. A 2= 3.52 ± 0.69). Irradiation reduced the edema (A 3= 0.84 ± 0.09; A4= 1.31 ± 0.05) and the COX-2 mRNA (A 3= 2.16 ± 0.28; A 4= 1.86 ± 0.20).

Conclusion:

LLLT reduce the expression of COX-2 mRNA.

Received 15 December 2006; returned for revision 19 January 2007; accepted by J. Di Battista 31 January 2007