Inflammation Research

, Volume 56, Issue 6, pp 228–229

COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy

  • R. Albertini
  • F. Aimbire
  • A. B. Villaverde
  • J. A. SilvaJr.
  • M. S. Costa
Short Communication

DOI: 10.1007/s00011-007-6211-6

Cite this article as:
Albertini, R., Aimbire, F., Villaverde, A.B. et al. Inflamm. res. (2007) 56: 228. doi:10.1007/s00011-007-6211-6

Abstract.

Objective and design:

Low level laser therapy (LLLT) has been presented as a novel therapy to treat inflammation. Herein we studied the effect of LLLT on the COX-2 mRNA expression in subplantar tissue taken from rats treated with carrageenan.

Material:

The groups consisted of 32 rats: A1 (Saline), A2 (Carrageenan), A3 (Carrageenan + laser 660 nm) and A4 (Carrageenan + laser 684 nm).

Treatment:

A3 and A4 were irradiated in the first hour after carrageenan.

Methods:

The edema was measured by a plethysmometer and COX-2 mRNA was by RT-PCR. Statistical were evaluated by ANOVA and Tukey-Kramer Test.

Results:

Carrageenan increased both edema (A1= 0.6 ± 0.04 vs. A2= 2.24 ± 0.08) and COX-2 mRNA (A1= 1.1 ± 0.26 vs. A2= 3.52 ± 0.69). Irradiation reduced the edema (A3= 0.84 ± 0.09; A4= 1.31 ± 0.05) and the COX-2 mRNA (A3= 2.16 ± 0.28; A4= 1.86 ± 0.20).

Conclusion:

LLLT reduce the expression of COX-2 mRNA.

Keywords:

InflammationCOX-2LLLT

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • R. Albertini
    • 1
  • F. Aimbire
    • 1
  • A. B. Villaverde
    • 1
  • J. A. SilvaJr.
    • 2
  • M. S. Costa
    • 1
  1. 1.IP&D – UNIVAP, AvSão José dos CamposBrazil
  2. 2.Departamento de Ciências da ReabilitaçãoUNINOVESPBrazil