Inflammation Research

, Volume 55, Issue 5, pp 177–178

Potential role for IL-23 in hepatic ischemia/reperfusion injury

  • T. L. Husted
  • J. Blanchard
  • R. Schuster
  • H. Shen
  • A. B. Lentsch
Short Communication

DOI: 10.1007/s00011-006-0073-1

Cite this article as:
Husted, T.L., Blanchard, J., Schuster, R. et al. Inflamm. res. (2006) 55: 177. doi:10.1007/s00011-006-0073-1

Summary.

IL-12 and IL-23 are related cytokines that share a p40 subunit. Our previous studies identified IL-12 as a primary initiator of the cytokine cascade induced after hepatic ischemia/reperfusion. Because those studies were conducted prior to the discovery of IL-23, it is not clear whether IL-12 or IL-23 is the relevant cytokine in this response. The current studies show that the antibodies used in our original study cross-react with IL-23. We also found that both IL-12 p35 and IL-23 p19 mRNA are expressed rapidly in the liver after ischemia/reperfusion. Finally, isolated Kupffer cells produced TNFα in response to IL-23, but not IL-12, suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion.

Keywords.

IL-23 IL-12 inflammation liver Kupffer cells 

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  • T. L. Husted
    • 1
  • J. Blanchard
    • 1
  • R. Schuster
    • 1
  • H. Shen
    • 1
  • A. B. Lentsch
    • 1
  1. 1.The Laboratory of Trauma, Sepsis & Inflammation Research, Department of SurgeryUniversity of Cincinnati College of MedicineCincinnatiUSA

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