, Volume 53, Issue 10, pp 509-516

Histamine H3-receptor isoforms

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Abstract.

Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.

Accepted by A. Falus 19 April 2004
Manuscript received a 1st prize from the European Histamine Research Society