Inflammation Research

, Volume 53, Issue 8, pp 338–343

Serum interleukin-10 in ICU patients with severe acute central nervous system injuries

  • P. Dziurdzik
  • L. Krawczyk
  • P. Jalowiecki
  • Z. Kondera-Anasz
  • L. Menon
Original Paper

DOI: 10.1007/s00011-004-1265-1

Cite this article as:
Dziurdzik, P., Krawczyk, L., Jalowiecki, P. et al. Inflamm. res. (2004) 53: 338. doi:10.1007/s00011-004-1265-1

Abstract

Rationale:IL-10, the main anti-inflammatory cytokine, may play a pivotal role in cerebral inflammation implicated in the development of brain edema and secondary brain damage after injury.

Aim of the study:1) Determining absolute IL-10 serum level and its pattern in critically ill patients with traumatic and non-traumatic acute brain injury. 2) Assessment of prognostic value of serum IL-10 in those patients.

Materials and methods:Serum IL-10 levels in 46 adults (multi-profile ICU, teaching hospital) with traumatic brain injury (TBI, N = 18), nontraumatic intracranial hemorrhage (SAH, N = 11) and polytrauma with concomitant brain injury (POL, N = 17) were measured using ELISA. Relationship of IL-10 and initial diagnosis, clinical state, outcome and risk of infection development was evaluated.

Results:IL-10 was detectable in the serum of all but one patient on ICU admission (56.6 ± 91.9 pg/ml; mean ± SD). No statistically significant differences in IL-10 between TBI, SAH and POL groups as well as between survivors and non-survivors on any day were found. No correlation between IL-10 and GCS or SAPS II was seen. Significant fall in serum IL-10 during the first 4 days of injury in patients of all subgroups was observed. Patients with initial serum IL-10 below 77pg/ml were at significantly higher risk of development of any infection within the first week of injury.

Conclusions:After acute brain injury, serum IL-10 in adults is detectable independent of CNS lesion type. Its systemic release is strongly individualized. Serum IL-10 on ICU admission may have some prognostic value to predict development of infection in patients with CNS lesions.

Interleukin-10 Central nervous system Brain injury Intensive care 

Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  • P. Dziurdzik
    • 1
  • L. Krawczyk
    • 1
  • P. Jalowiecki
    • 1
  • Z. Kondera-Anasz
    • 2
  • L. Menon
    • 1
  1. 1.Clinical Department of Anesthesiology and Intensive Care, Chair of Anesthesiology, Intensive Therapy and Emergency MedicineMedical University of Silesia, Katowice, PolandSosnowiecPoland
  2. 2.Chair and Department of Immunology and SerologyMedical University of Silesia, Katowice, PolandKatowicePoland