The Anti-Tumor Activity of E1A and its Implications in Cancer Therapy

Review

DOI: 10.1007/s00005-014-0273-2

Cite this article as:
Chang, YW., Hung, MC. & Su, JL. Arch. Immunol. Ther. Exp. (2014) 62: 195. doi:10.1007/s00005-014-0273-2

Abstract

The adenovirus type 5 E1A protein (E1A) plays a critical role in anti-cancer gene therapy and has been tested in clinical trials. The expression of E1A significantly reduces tumorigenesis, promotes cell death, and inhibits cancer cell mobility. Chemosensitization is one of the anti-tumor effects of E1A, increasing in vitro and in vivo sensitization of anti-cancer drugs, including cisplatin, gemcitabine, etoposide, doxorubicin, paclitaxel, and tumor necrosis factor-related apoptosis-inducing ligand and histone deacetylase inhibitors in different types of cancer cells. E1A also demonstrates anti-metastasis activity through various molecular mechanisms such as the repression of protease expression, suppression of HER2/neu and downregulation of microRNA (miR-520h). Moreover, E1A has been reported to reprogram transcription in tumor cells and stabilize tumor suppressors such as PP2A/C, p21 and p53. Because E1A plays a potentially significant role in anti-tumor therapy, there exists an urgent need to study the anti-cancer activities of E1A. This paper presents a review of our current understanding of the tumor-suppressive functions and molecular regulation of E1A, as well as the potential clinical applications of E1A.

Keywords

E1AGene therapyChemoresistanceMetastasis

Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2014

Authors and Affiliations

  • Yi-Wen Chang
    • 1
    • 2
  • Mien-Chie Hung
    • 3
    • 4
    • 5
    • 6
  • Jen-Liang Su
    • 3
    • 4
    • 5
    • 7
  1. 1.Graduate Institute of Biochemistry and Molecular BiologyNational Yang-Ming UniversityTaipeiTaiwan
  2. 2.Genomics Research CenterAcademia SinicaTaipeiTaiwan
  3. 3.Graduate Institute of Cancer BiologyChina Medical UniversityTaichungTaiwan
  4. 4.Department of BiotechnologyAsia UniversityTaichungTaiwan
  5. 5.Center for Molecular MedicineChina Medical University HospitalTaichungTaiwan
  6. 6.Department of Molecular and Cellular OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  7. 7.National Institute of Cancer ResearchNational Health Research InstitutesZhunanTaiwan