Archivum Immunologiae et Therapiae Experimentalis

, 57:291

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

Authors

    • Department of Medical MicrobiologyUniversity of Medical Sciences
  • Ryszard Marciniak
    • Department of General, Gastroenterological, and Endocrinological SurgeryUniversity of Medical Sciences
  • Izabela Chudzicka-Strugała
    • Department of Medical MicrobiologyUniversity of Medical Sciences
  • Agnieszka Wasilewska
    • Department of General, Gastroenterological, and Endocrinological SurgeryUniversity of Medical Sciences
  • Michał Drews
    • Department of General, Gastroenterological, and Endocrinological SurgeryUniversity of Medical Sciences
  • Przemysław Majewski
    • Department of Clinical PathomorphologyUniversity of Medical Sciences
  • Tomasz Karpiński
    • Department of Medical MicrobiologyUniversity of Medical Sciences
  • Barbara Zwoździak
    • Department of Medical MicrobiologyUniversity of Medical Sciences
Open AccessOriginal Article

DOI: 10.1007/s00005-009-0031-z

Cite this article as:
Szkaradkiewicz, A., Marciniak, R., Chudzicka-Strugała, I. et al. Arch. Immunol. Ther. Exp. (2009) 57: 291. doi:10.1007/s00005-009-0031-z

Abstract

Introduction

The aim of the study was to describe the levels of circulating monocyte/macrophage pro-inflammatory cytokines (TNF-α, IL-1β IL-6, and IL-8) and an anti-inflammatory cytokine (IL-10) in inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients and healthy controls.

Materials and Methods

The study was conducted on 15 healthy individuals, 20 patients with ulcerative colitis (UC), 12 with Crohn’s disease (CD), and 15 with CRC (Dukes’ stage B). Blood serum cytokine levels were measured by ELISA.

Results

The patients with UC had significantly higher levels of the pro-inflammatory cytokines and of circulating IL-10 than the healthy controls. The patients with CD and CRC had the same specific pattern of serum cytokines of significantly elevated levels of the pro-inflammatory cytokines, but the IL-10 levels were within the range found in the healthy individuals.

Conclusions

Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients.

Keywords

cytokines inflammation Crohn’s disease ulcerative colitis colorectal cancer

Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2009