Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients
The aim of the study was to describe the levels of circulating monocyte/macrophage pro-inflammatory cytokines (TNF-α, IL-1β IL-6, and IL-8) and an anti-inflammatory cytokine (IL-10) in inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients and healthy controls.
Materials and Methods
The study was conducted on 15 healthy individuals, 20 patients with ulcerative colitis (UC), 12 with Crohn’s disease (CD), and 15 with CRC (Dukes’ stage B). Blood serum cytokine levels were measured by ELISA.
The patients with UC had significantly higher levels of the pro-inflammatory cytokines and of circulating IL-10 than the healthy controls. The patients with CD and CRC had the same specific pattern of serum cytokines of significantly elevated levels of the pro-inflammatory cytokines, but the IL-10 levels were within the range found in the healthy individuals.
Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients.
- Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Archivum Immunologiae et Therapiae Experimentalis
Volume 57, Issue 4 , pp 291-294
- Cover Date
- Print ISSN
- Online ISSN
- SP Birkhäuser Verlag Basel
- Additional Links
- Crohn’s disease
- ulcerative colitis
- colorectal cancer
- Industry Sectors
- Author Affiliations
- 1. Department of Medical Microbiology, University of Medical Sciences, Wieniawskiego 3, 61-712, Poznań, Poland
- 2. Department of General, Gastroenterological, and Endocrinological Surgery, University of Medical Sciences, Poznań, Poland
- 3. Department of Clinical Pathomorphology, University of Medical Sciences, Poznań, Poland