Archivum Immunologiae et Therapiae Experimentalis

, 56:257

Role of the Wnt/β-catenin network in regulating hematopoiesis

REVIEW

DOI: 10.1007/s00005-008-0029-y

Cite this article as:
Wilusz, M. & Majka, M. Arch. Immunol. Ther. Exp. (2008) 56: 257. doi:10.1007/s00005-008-0029-y

Abstract

The Wnt/β-catenin pathway plays a significant role in several aspects of cell biology, including the stimulation of gene expression, growth, and mobility. Wnt proteins activate at least three cascades: Wnt/β-catenin, Wnt/Ca2+, and planar cell polarity. β-Catenin is not only a very important element of many intracellular signaling pathways, including the Wnt pathway, but it also takes part in creating intercellular adhesive junctions. When overexpressed or mutated it functions as an oncogen. The Wnt/β-catenin signaling pathway has been shown to play an important role in controlling the proliferation, survival, and differentiation of hematopoietic cells. Thus any aberrant signaling through this pathway may have a negative influence on hematopoiesis. Indeed, some recent findings suggest that Wnt/β-catenin signaling is dysregulated in leukemias and lymphomas. All these data position the Wnt/β-catenin signaling network as a critically important regulator of hematopoiesis and justify future efforts to better understand its role in the process of physiological and pathological hematopoiesis. The present review summarizes recent advances in this field.

Keywords:

Wntβ-cateninhematopoiesisstem cellstumor cells

Abbreviations

APC

adenomatous poliposis coli

BFU

base-forming unit

CFU

colony-forming unit

CMP

common myeloid progenitor

CTNNB1

cadherin-associated protein β-1

Dsh

Dvl-Dishevelled

Fzd

Frizzled

HSC

hematopoietic stem cell

IL

interleukin

LRP

LDL-receptor-related protein

PCP

planar cell polarity

SCF

stem cell factor

sFRP

secreted Frizzled-related protein

TCF

human T-cell factor

LEF

lymphoid enhancer factor

TGF-β

transforming growth factor-β

WIF-1

Wnt-inhibitory factor 1

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Department of Transplantation, Polish-American Institute of PediatricsJagiellonian UniversityCracowPoland