Modulation of apoptosis signaling for cancer therapy


DOI: 10.1007/s00005-006-0019-x

Cite this article as:
Fulda, S. & Debatin, KM. Arch. Immunol. Ther. Exp. (2006) 54: 173. doi:10.1007/s00005-006-0019-x


Apoptosis, the cell’s intrinsic death program, plays a central role in regulating tissue homeostasis. Also, most cytotoxic therapies used for cancer treatment, such as chemotherapy, γ-irradiation, suicide genes, or immunotherapy, predominantly act by triggering apoptosis in target cells. Thus, understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Therefore, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.


apoptosis cancer therapy resistance 

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.University Children’s HospitalUlmGermany

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