Modulation of apoptosis signaling for cancer therapy
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- Fulda, S. & Debatin, KM. Arch. Immunol. Ther. Exp. (2006) 54: 173. doi:10.1007/s00005-006-0019-x
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Apoptosis, the cell’s intrinsic death program, plays a central role in regulating tissue homeostasis. Also, most cytotoxic therapies used for cancer treatment, such as chemotherapy, γ-irradiation, suicide genes, or immunotherapy, predominantly act by triggering apoptosis in target cells. Thus, understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Therefore, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.