European Archives of Psychiatry and Clinical Neuroscience

, Volume 249, Supplement 3, pp S28–S36

Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes

Authors

  • B. Reisberg
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Emile H. Franssen
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Syed Mahmood Hasan
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Isabel Monteiro
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Istvan Boksay
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Liduin E. M. Souren
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Sunnie Kenowsky
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Stefanie R. Auer
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Shahid Elahi
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu
  • Alan Kluger
    • Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue New York, New York 10016, USA e-mail: barry.reisberg@med.nyu.edu

DOI: 10.1007/PL00014170

Cite this article as:
Reisberg, B., Franssen, E., Hasan, S. et al. European Archives of Psychiatry and Clinical Neurosciences (1999) 249: S28. doi:10.1007/PL00014170

Abstract

Data from clinical, electrophysiologic, neurophysiologic, neuroimaging and neuropathologic sources indicates that the progression of brain aging and Alzheimer’s disease (AD) deterioration proceeds inversely to human ontogenic acquisition patterns. A word for this process of degenerative developmental recapitulation, “retrogenesis”, has been proposed. These retrogenic processes provide new insights into the pathologic mechanism of AD deterioration. An understanding of retrogenic phenonmena can also result in insights into the applicability of retrogenic pathologic mechanisms for non-AD dementing disorders. Management strategies based upon retrogenesis have recently been proposed. Retrogenic pathophysiology also points to previously unexplored pharmacologic approaches to dementia prevention and treatment.

Key words Alzheimer’s diseaseDementiaRetrogenesisHuman development

Copyright information

© Steinkopff Verlag 1999